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Chemical Senses 21: 113-120,
© 1996

research-article

Anterior Tongue Stiomulation with Amiloride Suppresses NaCl Saltiness, but not Citric Acid Sourness in Humans

Ann M. Tennissen and N. Bruce McCutcheon1

Department of Psychology, College of Saint Rose Albany, NY 12203 1Department of Psychology, University at Albany Albany, NY 12222, USA

Correspondence to be sent to: Ann M. Tennissen, College of Saint Rose, School of Mathematics and Science, Albany, NY 12203, USA

Suppression of the saltiness of NaCI solutions by amiloride, a sodium channel blocker, has previously been reported a number of times in humans. This suppression was seen with techniques that involved stimulation of small areas of the tongue. It was not certain, however, whether amiloride would suppress saltiness with stimulation of a much larger area of the tongue; one published study, in fact, found negative results with whole mouth stimulation. For this study, eight subjects dipped a large part of the anterior portion of the tongue into a 10-ml sample of NaCI solution, or a NaCI and amiloride solution, and reported its magnitude of saltiness intensity. The results show that amiloride suppressed the saltiness of NaCI when a large area of the anterior tongue was stimulated. Consistent with previous studies, there was individual variability across subjects in this suppressive effect of amiloride. This study also used this method to test the effects of amiloride on the sourness of citric acid, which was not expected to be affected. No suppression of sourness was seen with amiloride. Chem. Senses 21: 113–120, 1996.


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