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Chem. Senses 25: 313-322, 2000
© Oxford University Press 2000

Cyclic Adenosine Monophosphate Signaling in the Rat Vomeronasal Organ: Role of an Adenylyl Cyclase Type VI

Patricia Rössler, Christine Kroner1, Jürgen Krieger, Dietrich Löbel, Heinz Breer and Ingrid Boekhoff

Institute of Physiology, University of Stuttgart–Hohenheim, D-70593 Stuttgart, Germany and 1 Department of Haematology, University Medical Center, Utrecht, The Netherlands

Correspondence to be sent to: Ingrid Boekhoff, Institute of Physiology, University of Stuttgart–Hohenheim, D-70593 Stuttgart, Germany. e-mail: boekhoff{at}uni-hohenheim.de

The present study indicates that male rat urinary components in female rat vomeronasal organ microvillar preparations not only induce a rapid and transient IP3 signal, but in addition, the level of cAMP decreases with a delayed and sustained time course. This decrease seems to be a consequence of the preceding activation of the phosphoinositol pathway rather than the result of an enhanced phosphodiesterase activity or an inhibition of adenylyl cyclase (AC) via G{alpha}i or G{alpha}o. This notion is supported by the finding that activation of the endogenous protein kinase C suppresses basal as well as forskolin-induced cAMP formation. Furthermore, it was observed that elevated levels of calcium inhibit cAMP formation in rat VNO microvillar preparations. These properties of cAMP signaling in the VNO of rats may be mediated by a calcium- and protein kinase C-inhibited AC VI subtype, which is localized in microvillar preparations of the VNO.


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