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Chemical Senses 19: 47-56,
© 1994

research-article

Olfactory-evoked potentials: assessment of young and elderly, and comparison to psychophysical threshold

Claire Murphy1,4, Steven Nordin1, René A. de Wijk2, William S. Cain2 and John Polich3

1San Diego State University and University of California Medical Center San Diego 2John B.Pierce Laboratory and Yale University New Haven, CT 3The Scripps Research Institute La Jolla, CA, USA

4To whom correspondence should be addressed: Department of Psychology, College of Sciences, San Diego State University, San Diego, CA 92182, USA

Olfactory-evoked potentials (OEPs) were recorded monopolarly at the Fz, Cz and Pz electrode sites in young adults and elderly subjects with an amyl acetate stimulus presented olfactometrically. Psychophysical odor thresholds for amyl acetate were determined using a two-alternative, forced-choice detection procedure. These demonstrated a decreased odor detection sensitivity in the elderly relative to the young subjects. In accordance with the threshold findings, elderly subjects produced significantly smaller N1 and P2 amplitudes, and a trend towards longer latencies than younger subjects. Moreover, odor threshold was found to correlate with amplitude magnitude. The OEP findings, which are discussed in the context of previous OEP studies, offer promise as an objective, non-invasive measure of sensory function in both clinical and non-clinical settings.


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